Knowledge about 2-Cyanophenol

2-Cyanophenol, commonly known as salicylic nitrile, also known as 2-hydroxybenzonitrile, etc., has a certain water solubility, Pka=7.17, and is unstable to strong alkalis and oxidants. 2-Cyanophenol is an off-white powdery solid with a very pungent odor. A small amount can affect your breathing, and the odor is bitter; if a small amount of salicylic nitrile is left open without ventilation, the odor can quickly spread throughout the room; therefore Protective measures must be taken during operation to reduce irritation to the respiratory tract.2-Cyanophenol use:2-Cyanophenol is used in the synthesis of CDK/GSK-3 inhibitors and used as a therapeutic agent for Alzheimer's disease. 2-Cyanophenol can be used as a pharmaceutical intermediate to synthesize bunolol hydrochloride for the treatment of hypertension and angina pectoris. As a pesticide intermediate, it can be used to synthesize the fungicide Mycelium, and it can also synthesize a variety of spices and liquid crystal materials.2-CyanophenolProduction method:The method for synthesizing 2-Cyanophenol by adopting a microchannel reactor, using o-hydroxybenzamide and phosgene as reactant raw materials to synthesize 2-Cyanophenol, includes the following steps:1. Pre-treatment of the reactants, dissolve 50g (0.36mol) of o-hydroxybenzamide in toluene to prepare 167g of o-hydroxybenzamide solution with a mass concentration of 30%;2. Set the reaction conditions of the microchannel reactor. Connect the heat exchange fin integrated with the reaction plate in the microchannel reactor to the external heating and cooling circulator. The heat exchange medium in the heat exchange fin is heat transfer oil. Set the reaction temperature of the microchannel reactor by heating and cooling the circulator;3. The synthesis of 2-Cyanophenol, using 30% mass concentration o-hydroxybenzamide solution and 98% purity phosgene as raw materials, react in a microchannel reactor to synthesize 2-Cyanophenol products: Different flow pumps are used to pass the o-hydroxybenzamide solution and phosgene into the feed port of the microchannel reactor at a certain feed flow rate. The o-hydroxybenzamide solution and phosgene are sequentially preheated in the microchannel reactor. Flow mixing and reaction to obtain a reaction product mixture, in which the molar ratio of the feed amount of o-hydroxybenzamide molecules and phosgene molecules is adjusted to 1:1.4 by a flow pump, and the feed flow rate of the o-hydroxybenzamide solution is 6mL/min The phosgene feed flow rate is 3mL/min; the reaction residence time in the microchannel reactor during this reaction process is 80s, the reaction temperature is 100°C, and the pressure is 0.8Mpa;4. The post-treatment of the reactants, the reaction product mixture synthesized in step S3 is separated into the gas phase and the liquid phase through a gas-liquid cooling separator, wherein the gas phase is recovered by a gas collection tank for post-processing, and the liquid phase is cooled and crystallized and filtered by suction. Obtain 40g of 2-Cyanophenol product and filtrate. The total conversion rate of o-hydroxybenzamide is 100%, the content of 2-Cyanophenol is 98.5%, the selectivity is 92%, and the yield is 92% (based on o-hydroxybenzamide). count).Clent Chemical is a supplier of 2-Cyanophenol. We have professional technology to ensure product quality. If you want to know more about 2-Cyanophenol, please continue to pay attention to our website. We will regularly update related articles and information about 2-Cyanophenol, and look forward to your visit and consultation.